Protein kinases critically regulate synaptic plasticity in the mammalian hippocampus. Cyclic-
AMP dependent protein kinase (PKA) is a serine–threonine kinase that has been strongly …

In neurons, appropriate long-term adaptive responses to changes in the environment
require the conversion of extracellular stimuli into discrete intracellular signals. Many of …

Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant
and possesses neuroprotective effects. Brain-derived neurotrophic factor (BDNF) and cyclic …

Phosphorylation of glutamate receptors (GluRs) is emerging as an important regulatory
mechanism. In this study 32P labeling of non-NMDA GluRs was investigated in cultured …

Addiction to drug and alcohol is regarded as a major health problem worldwide for which
available treatments show limited effectiveness. The biggest challenge remains to enhance …

Ependymin, a glycoprotein of the brain ECF, has been implicated in the neurochemistry of
memory and neuronal regeneration. Three behavioral experiments (swimming with a float …

Autophosphorylation of CaM kinase II on Thr286 is known to occur by an intraholoenzyme
mechanism, but it is not known whether this reaction is intra-or intersubunit-catalyzed in the …

Numerous studies over the past decade have established a role (s) for protein
phosphorylation in modulation of synaptic efficiency. This article reviews this data and …

Multiple trains of high-frequency synaptic stimulation evoke long-term potentiation (LTP) of
synaptic transmission in hippocampal area CA1, which has been correlated with …

One of the most active areas of neurobiology research concerns mechanisms involved in
paradigms of synaptic plasticity. A popular model for cellular leaning and memory is long …