As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …

The volume of the cell nucleus varies across cell types and species and is commonly
thought to be determined by the size of the genome and degree of chromatin compaction …

Nestor–Guillermo progeria syndrome (NGPS) is caused by a homozygous alanine-to-
threonine mutation at position 12 (A12T) in barrier-to-autointegration factor (BAF). It is …

Changing environmental conditions necessitate rapid adaptation of cytoplasmic and nuclear
volumes. We use the slime mold Dictyostelium discoideum, known for its ability to tolerate …

Nuclear membrane rupture during interphase occurs in a variety of cell contexts, both
healthy and pathological. Membrane ruptures can be rapidly repaired, but these …

Maintaining homeostasis is a fundamental characteristic of living systems. In cells, this is
contributed to by the assembly of biochemically distinct organelles, many of which are not …

Although textbook pictures depict the cell nucleus as a simple ovoid object, it is now clear
that it adopts a large variety of shapes in tissues. When cells deform, because of cell …

The nuclear envelope compartmentalizes the eukaryotic genome, provides mechanical
resistance, and regulates access to the chromatin. However, recent studies have identified …

Nucleus position in cells can act as a developmental cue. Mammalian oocytes position their
nucleus centrally using an F-actin-mediated pressure gradient. The biological significance of …