Muscle contraction and a range of critical cellular functions rely on force-producing
interactions between myosin motors and actin filaments, powered by turnover of adenosine …

Release of the ATP hydrolysis product ortophosphate (Pi) from the active site of myosin is
central in chemo‐mechanical energy transduction and closely associated with the main …

Mechanistic insights into myosin II energy transduction in striated muscle in health and
disease would benefit from functional studies of a wide range of point‐mutants. This …

Many biological molecular motors and machines are driven by chemical reactions that occur
in specific catalytic sites. We study whether the arrival of molecules to such an active site can …

The current understanding of protein function predominantly relies on the concept of
describing proteins as comprising discrete conformational and chemical states including …

Double-strand DNA breaks are the severest type of genomic damage, requiring rapid
response to ensure survival. RecBCD helicase in prokaryotes initiates processive and rapid …