Conditional Cell Reprogramming and Air–Liquid Interface Modeling Life Cycle of Oncogenic Viruses (HPV and EBV) in Epithelial Cells and Virus-Associated Human …

AQ Rani, D Nurmemet, J Liffick, A Khan, D Mitchell, J Li… - Viruses, 2023 - mdpi.com
Several oncogenic viruses are associated with approximately 20% of human cancers.
Experimental models are crucial for studying the pathogenicity and biological aspects of …

Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells

N Van Sciver, M Ohashi, NP Pauly, JA Bristol… - PLoS …, 2021 - journals.plos.org
The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell
malignancies, and both the latent and lytic forms of viral infection contribute to the …

Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry …

SL Faley, NA Boghdeh, DK Schaffer, EC Spivey… - Lab on a Chip, 2024 - pubs.rsc.org
Human microphysiological systems, such as organs on chips, are an emerging technology
for modeling human physiology in a preclinical setting to understand the mechanism of …

Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells

Y Yang, T Ding, Y Cong, X Luo, C Liu, T Gong… - Nature …, 2024 - nature.com
Epstein–Barr virus (EBV) can infect both B cells and epithelial cells (ECs), causing diseases
such as mononucleosis and cancer. It enters ECs via Ephrin receptor A2 (EphA2). The …

ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells

N Van Sciver, M Ohashi, DM Nawandar… - PLoS …, 2021 - journals.plos.org
Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and
contributes to both B-cell and epithelial-cell malignancies. EBV-infected epithelial cell …

Serologic profiling using an Epstein-Barr virus mammalian expression library identifies EBNA1 IgA as a prediagnostic marker for nasopharyngeal carcinoma

S Paudel, BE Warner, R Wang, J Adams-Haduch… - Clinical Cancer …, 2022 - AACR
Purpose: The favorable prognosis of stage I and II nasopharyngeal carcinoma (NPC) has
motivated a search for biomarkers for the early detection and risk assessment of Epstein …

Aerosol–cell exposure system applied to semi-adherent cells for aerosolization of lung surfactant and nanoparticles followed by high quality RNA extraction

MM Leroux, R Hocquel, K Bourge, B Kokot, H Kokot… - Nanomaterials, 2022 - mdpi.com
Nanoparticle toxicity assessments have moved closer to physiological conditions while
trying to avoid the use of animal models. An example of new in vitro exposure techniques …

In Vitro Characteristics of Canine Primary Tracheal Epithelial Cells Maintained at an Air–Liquid Interface Compared to In Vivo Morphology

S Runft, I Färber, J Krüger, K Schöne… - International Journal of …, 2023 - mdpi.com
Culturing respiratory epithelial cells at an air–liquid interface (ALI) represents an established
method for studies on infection or toxicology by the generation of an in vivo-like respiratory …

Three-dimensional models of the nasopharynx for the study of Epstein-Barr virus infection

P Ziegler, AS Reznik, SP Kitchloo, E Wang, SE Lee… - Bio …, 2022 - bio-protocol.org
The ubiquitous and cancer-associated Epstein-Barr virus (EBV) is associated with nearly all
cases of nasopharyngeal carcinoma (NPC). Nasopharyngeal tissue is comprised of both …

[图书][B] The regulation of EBV lytic reactivation in epithelial cells

N Van Sciver - 2021 - search.proquest.com
Epstein-Barr virus (EBV) is a herpesvirus infecting> 90% of the population. An EBV infection
can be latent, where few genes are expressed, or lytic, where the entire viral gene …