Dengue, West Nile, and Zika Viruses: potential novel antiviral biologics drugs currently at discovery and preclinical development stages

IC Martins, RC Ricardo, NC Santos - Pharmaceutics, 2022 - mdpi.com
Dengue, West Nile and Zika viruses are vector-borne flaviviruses responsible for numerous
disease outbreaks in both Hemispheres. Despite relatively low mortality, infection may lead …

Differential receptor-mediated drug targeting to the diseased brain

J Rip, GJ Schenk, AG De Boer - Expert opinion on drug delivery, 2009 - Taylor & Francis
The brain is not directly accessible for intravenously administered macro-and most small
molecular drugs because of the presence of the blood–brain barrier (BBB). In this respect …

Exercise pre-conditioning reduces brain inflammation and protects against toxicity induced by traumatic brain injury: behavioral and neurochemical approach

BC Mota, L Pereira, MA Souza, LFA Silva… - Neurotoxicity …, 2012 - Springer
Although the favorable effects of physical exercise in neurorehabilitation after traumatic
brain injury (TBI) are well known, detailed pathologic and functional alterations exerted by …

Lumateperone normalizes pathological levels of acute inflammation through important pathways known to be involved in mood regulation

S Dutheil, LS Watson, RE Davis… - Journal of …, 2023 - Soc Neuroscience
Lumateperone is indicated for the treatment of schizophrenia in adults and for depressive
episodes associated with bipolar I or II disorder (bipolar depression) in adults, as …

Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8+ T-Cells

D Růžek, J Salát, SK Singh, J Kopecký - PLoS One, 2011 - journals.plos.org
Tick-borne encephalitis (TBE) virus causes severe encephalitis with serious sequelae in
humans. The disease is characterized by fever and debilitating encephalitis that can …

Physical exercise ameliorates deficits induced by traumatic brain injury

T Archer, K Svensson… - Acta Neurologica …, 2012 - Wiley Online Library
The extent and depth of traumatic brain injury (TBI) remains a major determining factor
together with the type of structural insult and its location, whether mild, moderate or severe …

Increased blood–brain barrier permeability is not a primary determinant for lethality of West Nile virus infection in rodents

JD Morrey, AL Olsen, V Siddharthan… - Journal of General …, 2008 - microbiologyresearch.org
Blood–brain barrier (BBB) permeability was evaluated in mice and hamsters infected with
West Nile virus (WNV, flavivirus) as compared to those infected with Semliki Forest …

In Vitro Infection with Dengue Virus Induces Changes in the Structure and Function of the Mouse Brain Endothelium

ML Velandia-Romero, MA Calderón-Peláez… - PLoS …, 2016 - journals.plos.org
Background The neurological manifestations of dengue disease are occurring with greater
frequency, and currently, no information is available regarding the reasons for this …

[HTML][HTML] Comprehensive assessment of the genetics and virulence of tick-borne encephalitis virus strains isolated from patients with inapparent and clinical forms of …

GN Leonova, SI Belikov, IG Kondratov, I Takashima - Virology, 2013 - Elsevier
We analyzed the genetics and virulence of 35 strains of TBEV isolated from patients with
different forms of the infection living in the southern Far East region of Russia. The results of …

West nile virus and equine encephalitis viruses: New perspectives

MT Long - Veterinary Clinics: Equine Practice, 2014 - vetequine.theclinics.com
The genus Alphavirus belongs to the family Togaviridae and includes several viruses that
have been isolated from horses with neurologic disease. Of these alphaviruses, Eastern …