Preeclampsia and diabetes

TL Weissgerber, LM Mudd - Current diabetes reports, 2015 - Springer
Preeclampsia is diagnosed in women presenting with new onset hypertension accompanied
by proteinuria or other signs of severe organ dysfunction in the second half of pregnancy …

Improving pregnancy outcomes in women with diabetes mellitus: modern management

L Ringholm, P Damm, ER Mathiesen - Nature Reviews Endocrinology, 2019 - nature.com
Women with pre-existing (type 1 or type 2) diabetes mellitus are at increased risk of
pregnancy complications, such as congenital malformations, preeclampsia and preterm …

Risk of pre‐eclampsia in women taking metformin: a systematic review and meta‐analysis

A Alqudah, MC McKinley, R McNally… - Diabetic …, 2018 - Wiley Online Library
Aims To perform meta‐analyses of studies evaluating the risk of pre‐eclampsia in high‐risk
insulin‐resistant women taking metformin prior to, or during pregnancy. Methods A search …

Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus

AM Nuzzo, D Giuffrida, L Moretti, P Re, G Grassi… - Scientific Reports, 2021 - nature.com
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by
endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a …

Diabetic nephropathy and pregnancy

K Bramham - Seminars in nephrology, 2017 - Elsevier
Women with diabetic nephropathy have challenging pregnancies, with pregnancy outcomes
far worse than expected for the stage of chronic kidney disease. The underlying …

Systematic characterization of autophagy in gestational diabetes mellitus

L Ji, Z Chen, Y Xu, G Xiong, R Liu, C Wu, H Hu… - …, 2017 - academic.oup.com
Autophagy is a dynamic process that degrades and recycles cellular organelles and
proteins to maintain cell homeostasis. Alterations in autophagy occur in various diseases; …

The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes

AL Cohen, JB Wenger, T James-Todd… - Hypertension in …, 2014 - Taylor & Francis
Objective: To assess whether glycemic control, soluble fms-like tyrosine kinase 1 (sFlt1) and
placental growth factor (PlGF) were associated with the development of preeclampsia (PE) …

The association of falling insulin requirements with maternal biomarkers and placental dysfunction: a prospective study of women with preexisting diabetes in …

S Padmanabhan, VW Lee, M Mclean… - Diabetes …, 2017 - Am Diabetes Assoc
OBJECTIVE To investigate the association of falling insulin requirements (FIR) among
women with preexisting diabetes with adverse obstetric outcomes and maternal biomarkers …

Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study

M Azar, A Basu, AJ Jenkins, AJ Nankervis… - Diabetes …, 2011 - Am Diabetes Assoc
OBJECTIVE Increased oxidative stress and immune dysfunction are implicated in
preeclampsia (PE) and may contribute to the two-to fourfold increase in PE prevalence …

An examination of the effect of aspirin and salicylic acid on soluble fms-like tyrosine kinase-1 release from human placental trophoblasts

J Zhao, R Duan, J Sun, RP Chow, TJ Lyons, JY Yu - Cells, 2024 - mdpi.com
Low-dose aspirin (LDA) is efficacious in preventing preeclampsia, but its mechanism of
action is unclear. Conflicting evidence suggests that it may inhibit placental trophoblast …