Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni
FC Lombardo, V Pasche, G Panic, Y Endriss… - Nature Protocols, 2019 - nature.com
Drug discovery for schistosomiasis is still limited to a handful of academic laboratories
worldwide, with only a few novel antischistosomal lead compounds being actively …
worldwide, with only a few novel antischistosomal lead compounds being actively …
The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin
Schistosomes are intravascular, parasitic flatworms that cause debilitating disease afflicting>
200 million people. Proteins expressed at the host-parasite interface likely play key roles in …
200 million people. Proteins expressed at the host-parasite interface likely play key roles in …
Genetic and molecular characterization of the immortalized murine hepatic stellate cell line GRX
SK Schröder, HM Schüler, KV Petersen, C Tesauro… - Cells, 2022 - mdpi.com
The murine cell line GRX has been introduced as an experimental tool to study aspects of
hepatic stellate cell biology. It was established from livers of C3H/HeN mice that were …
hepatic stellate cell biology. It was established from livers of C3H/HeN mice that were …
Demonstration of N,N-Dimethyldithiocarbamate as a Copper-Dependent Antibiotic against Multiple Upper Respiratory Tract Pathogens
SV Menghani, A Rivera, M Neubert… - Microbiology …, 2021 - Am Soc Microbiol
Transition metals are necessary cofactors and structural elements in living systems.
Exposure to high concentrations of biologically important transition metals, such as zinc and …
Exposure to high concentrations of biologically important transition metals, such as zinc and …
Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni
BP Moreira, ICA Batista, NC Tavares… - Frontiers in Cellular …, 2022 - frontiersin.org
Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the
main drug for treatment, despite its low effectiveness against early stages of the worm. To …
main drug for treatment, despite its low effectiveness against early stages of the worm. To …
A novel duplex ddPCR assay for the diagnosis of schistosomiasis japonica: proof of concept in an experimental mouse model
The current World Health Organization strategic plan targets the elimination of
schistosomiasis as a public health problem by 2025 and accurate diagnostics will play a …
schistosomiasis as a public health problem by 2025 and accurate diagnostics will play a …
Mechanically produced schistosomula as a higher-throughput tools for phenotypic pre-screening in drug sensitivity assays: current research and future trends
EM Tekwu, WK Anyan, D Boamah… - Biomarker …, 2016 - Springer
It is crucial to develop new antischistosomal drugs since there is no vaccine and the whole
world is relying on only a single drug for the treatment of schistosomiasis. One of the …
world is relying on only a single drug for the treatment of schistosomiasis. One of the …
Comparative Study of Transcriptome Profiles of Mechanical- and Skin-Transformed Schistosoma mansoni Schistosomula
AV Protasio, DW Dunne… - PLoS neglected tropical …, 2013 - journals.plos.org
Schistosome infection begins with the penetration of cercariae through healthy unbroken
host skin. This process leads to the transformation of the free-living larvae into obligate …
host skin. This process leads to the transformation of the free-living larvae into obligate …
First in silico screening of insect molecules for identification of novel anti-parasitic compounds
TL Gallinger, SY Aboagye, W Obermann, M Weiss… - Pharmaceuticals, 2022 - mdpi.com
Schistosomiasis is a neglected tropical disease caused by blood flukes of the genus
Schistosoma. In silico screenings of compounds for the identification of novel anti-parasitic …
Schistosoma. In silico screenings of compounds for the identification of novel anti-parasitic …
Optimisation of a droplet digital PCR assay for the diagnosis of Schistosoma japonicum infection: a duplex approach with DNA binding dye chemistry
Schistosomiasis is a chronically debilitating helminth infection with a significant socio-
economic and public health impact. Accurate diagnostics play a pivotal role in achieving …
economic and public health impact. Accurate diagnostics play a pivotal role in achieving …