Congenital long QT syndrome
Congenital long QT syndrome (LQTS) encompasses a group of heritable conditions that are
associated with cardiac repolarization dysfunction. Since its initial description in 1957, our …
associated with cardiac repolarization dysfunction. Since its initial description in 1957, our …
Electroimmunology and cardiac arrhythmia
J Grune, M Yamazoe, M Nahrendorf - Nature reviews cardiology, 2021 - nature.com
Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …
owing to the increasing age and body mass of the general population, because both are risk …
NaV1. 5 autoantibodies in Brugada syndrome: pathogenetic implications
Abstract Background and Aims Patients suffering from Brugada syndrome (BrS) are
predisposed to life-threatening cardiac arrhythmias. Diagnosis is challenging due to the …
predisposed to life-threatening cardiac arrhythmias. Diagnosis is challenging due to the …
The efficacy of Beta-blockers in patients with Long QT Syndrome 1–3 according to individuals' gender, Age, and QTc intervals: A Network Meta-analysis
L Han, F Liu, Q Li, T Qing, Z Zhai, Z Xia… - Frontiers in …, 2020 - frontiersin.org
Long QT syndrome (LQTS) is an arrhythmic heart disease caused by congenital genetic
mutations, and results in increased occurrence rates of polymorphic ventricular …
mutations, and results in increased occurrence rates of polymorphic ventricular …
Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes
DJ Clemens, D Ye, L Wang, CSJ Kim, W Zhou… - Stem Cell Reports, 2023 - cell.com
Triadin knockout syndrome (TKOS) is a malignant arrhythmia disorder caused by recessive
null variants in TRDN-encoded cardiac triadin. Induced pluripotent stem cell-derived …
null variants in TRDN-encoded cardiac triadin. Induced pluripotent stem cell-derived …
The role of autoantibodies in arrhythmogenesis
J Li - Current cardiology reports, 2021 - Springer
Abstract Purpose of Review The role of autoantibodies in arrhythmogenesis has been the
subject of research in recent times. This review focuses on the rapidly expanding field of …
subject of research in recent times. This review focuses on the rapidly expanding field of …
Endocannabinoids enhance hKV7. 1/KCNE1 channel function and shorten the cardiac action potential and QT interval
Background Genotype-positive patients who suffer from the cardiac channelopathy Long QT
Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown …
Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown …
Computational analysis of long QT syndrome type 2 and the therapeutic effects of KCNQ1 antibodies
Z Pan, Q Fu, H Jiang, Z Wei, S Zhang - Digital Health, 2024 - journals.sagepub.com
Objective Long QT interval syndrome (LQTS) is a highly dangerous cardiac disease that can
lead to sudden cardiac death; however, its underlying mechanism remains largely unknown …
lead to sudden cardiac death; however, its underlying mechanism remains largely unknown …
Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants
L Zhong, Z Yan, D Jiang, KC Weng, Y Ouyang… - Circulation …, 2024 - ahajournals.org
BACKGROUND: The KCNQ1+ KCNE1 (IKs) potassium channel plays a crucial role in
cardiac adaptation to stress, in which β-adrenergic stimulation phosphorylates the IKs …
cardiac adaptation to stress, in which β-adrenergic stimulation phosphorylates the IKs …
Cardiac arrhythmias: the growing role of autoantibodies in diagnosis and treatment
Role of autoantibodies against atrial and ventricular ion channels in cardiac arrhythmias and
their therapeutic potential. Autoantibodies targeting various cardiac ion channels can have …
their therapeutic potential. Autoantibodies targeting various cardiac ion channels can have …