Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …

Population aging and the obesity epidemic are important global public health problems that
pose an unprecedented threat to the physical and mental health of the elderly and health …

Systematic characterizations of adipose regulatory T (Treg) cell subsets and their
phenotypes remain uncommon. Using single-cell ATAC-sequencing and paired single-cell …

The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Abstract Uncoupling protein 1 (UCP1) has been discovered as a possible target for obesity
treatment because of its widespread distribution in the inner mitochondrial membrane of …

Extracellular purinergic molecules act as signaling molecules that bind to cellular receptors
and regulate signaling pathways. Growing evidence suggests that purines regulate …

Adenosine is one of the most ancient signaling molecules and has receptors in both animals
and plants. In mammals there are four specific receptors, A 1, A 2A, A 2B, and A 3, which …