In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Ventricular fibrillation (VF) is one of the main causes of death in the Western world.
According to one hypothesis, the chaotic excitation dynamics during VF are the result of …

Defining the cellular electrophysiological mechanisms for ventricular tachyarrhythmias is
difficult, given the wide array of potential mechanisms, ranging from abnormal automaticity to …

The heart is a nonlinear biological system that can exhibit complex electrical dynamics,
complete with period-doubling bifurcations and spiral and scroll waves that can lead to …

Despite the initial excitement over cancer vaccines, the clinical effectiveness of
immunotherapy has been disappointing. The suppressive milieu present within established …

Individuals with chronic heart failure (CHF) have an increased risk of ventricular arrhythmias,
which has been linked to pathological cellular remodeling and may also be mediated by …

Spatial dispersion of refractoriness, which is amplified by genetic diseases, drugs, and
electrical and structural remodeling during heart disease, is recognized as a major factor …

Cardiac arrhythmias are heart-rhythm disorders. Most arrhythmias are not life threatening,
and many are benign. But some rhythm disturbances originating in the ventricles—the …

Background—Dynamically induced heterogeneities of repolarization may lead to wave-front
destabilizations and initiation of ventricular fibrillation (VF). In a computer modeling study …

A beat-to-beat alternation in the action potential duration (APD) of myocytes, ie alternans, is
believed to be a direct precursor of ventricular fibrillation in the whole heart. A common …