Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology

Z Wang, Y Liu, X Niu - Seminars in Cancer Biology, 2023 - Elsevier
Gastric cancer is a leading contributor to cancer incidence and mortality globally. Recently,
artificial intelligence approaches, particularly machine learning and deep learning, are …

PD-L1: Biological mechanism, function, and immunotherapy in gastric cancer

Y Zhang, Y Yang, Y Chen, W Lin, X Chen, J Liu… - Frontiers in …, 2022 - frontiersin.org
Gastric cancer (GC) is one of the main causes of cancer incidence rate and mortality
worldwide. As the main breakthrough direction, the application of immune checkpoint …

Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial

YL Verschoor, J van de Haar, JG van den Berg… - Nature medicine, 2024 - nature.com
Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite
recent advancements, most patients die of their disease. Although immune checkpoint …

The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or …

Z Tang, Y Wang, D Liu, X Wang, C Xu, Y Yu… - Nature …, 2022 - nature.com
The synergistic effect of neoadjuvant immunotherapy and chemoradiotherapy in gastric
adenocarcinoma is unclear. This phase II trial (NCT03631615) investigated this neoadjuvant …

Neoadjuvant sintilimab in combination with concurrent chemoradiotherapy for locally advanced gastric or gastroesophageal junction adenocarcinoma: a single-arm …

J Wei, X Lu, Q Liu, Y Fu, S Liu, Y Zhao, J Zhou… - Nature …, 2023 - nature.com
In this multicenter, single-arm phase 2 trial (ChiCTR1900024428), patients with locally
advanced gastric/gastroesophageal junction cancers receive one cycle of sintilimab (anti …

Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

SQ Yuan, RC Nie, Y Jin, CC Liang, YF Li, R Jian… - Nature Medicine, 2024 - nature.com
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-
esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is …

Predictive biomarkers for immunotherapy in gastric cancer: current status and emerging prospects

W Hou, Y Zhao, H Zhu - International Journal of Molecular Sciences, 2023 - mdpi.com
Gastric cancer presents substantial management challenges, and the advent of
immunotherapy has ignited renewed hope among patients. Nevertheless, a significant …

Efficacy and safety of sintilimab plus XELOX as a neoadjuvant regimen in patients with locally advanced gastric cancer: A single-arm, open-label, phase II trial

H Guo, P Ding, C Sun, P Yang, Y Tian, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Background Neoadjuvant chemotherapies have been widely recommended in patients with
locally advanced gastric cancer (LAGC). However, the evidence of combining neoadjuvant …

Visual analysis of global research on immunotherapy for gastric cancer: a literature mining from 2012 to 2022

Y Chen, Y Chen, S Tan, Y Zheng, S Liu… - Human Vaccines & …, 2023 - Taylor & Francis
Gastric cancer (GC) is one of the most common malignancies. Immunotherapy becomes an
indispensable part of GC. This study conducts bibliometric analysis of immunotherapy for …

PD‑1/PD‑L1 immune checkpoint inhibitors in neoadjuvant therapy for solid tumors

Q Tang, S Zhao, N Zhou, J He… - International …, 2023 - spandidos-publications.com
A comprehensive search regarding programmed cell death protein 1 (PD‑1)/programmed
death‑ligand 1 (PD‑L1) inhibitor monotherapy or combination therapy in neoadjuvant …