The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

We survey the historical development of scientific knowledge surrounding Vitamin B3, and
describe the active metabolite forms of Vitamin B3, the pyridine dinucleotides NAD+ and …

Abstract Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide
(NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them …

Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …

Nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for nicotinamide
adenine dinucleotide (NAD+) synthesis, and Sirt1, an NAD+-dependent histone …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Diabetes and obesity are worldwide health problems. White fat dynamically participates in
hormonal and inflammatory regulation. White adipose tissue is recognized as a multifactorial …

Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors
termed adipokines. Visfatin was initially identified as a novel adipokine with insulin‐mimetic …

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of
NAD+-dependent enzymes that have been connected to a steadily growing set of biological …