Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic
material in lysosomes. The process promotes cellular fidelity, and while the core machinery …

Eukaryotic gene expression is regulated by enhancer–promoter interactions but the
molecular mechanisms that govern specificity have remained elusive. Genome-wide studies …

Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the
treatment of diverse diseases, yet the roles of individual BET family members remain …

Formation of self-associating loop domains is a fundamental organizational feature of
metazoan genomes. Here, we employed quantitative live-imaging methods to visualize …

A long-standing mystery in the field of Polycomb and Trithorax regulation is how these
proteins, which are highly conserved between flies and mammals, can regulate several …

Over 60 bromodomains belonging to proteins with very different functions have been
identified in humans. Several of them interact with acetylated lysine residues, leading to the …

Enhancers govern transcription through multiple mechanisms, including the regulation of
elongation by RNA polymerase II (RNAPII). We characterized the dynamics of looped …

Abstract Polycomb (PcG) and Trithorax (TrxG) group proteins give stable epigenetic memory
of silent and active gene expression states, but also allow poised states in pluripotent cells …