A recent increase in the literature regarding the evidence base for clozapine has made it
increasingly difficult for clinicians to judge “best evidence” for clozapine use. As such, we …

Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Background Clozapine effectiveness in the treatment of refractory schizophrenia has been
sustained by published evidence in the last two decades, despite the introduction of safer …

Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and
neurobiological background that influences early brain development, and is expressed as a …

These updated guidelines from the British Association for Psychopharmacology replace the
original version published in 2011. They address the scope and targets of pharmacological …

Although treatment-resistant schizophrenia (TRS) was described 50 years ago 1 and has a
gold standard treatment with clozapine based on well-defined criteria, 2 there is still a matter …

Negative symptoms (such as amotivation and diminished expression) associated with
schizophrenia are a major health concern. Adequate treatment would mean important …

Objective: Based on a substantial literature, olanzapine appears to be one of the most
efficacious antipsychotics marketed in the United States, with only clozapine clearly more …

Schizophrenia is a highly disabling disorder whose causes remain to be better understood,
and treatments have to be improved. However, several recent advances have been made in …