The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

Viral sequence classification has wide applications in clinical, epidemiological, structural
and functional categorization studies. Most existing approaches rely on an initial alignment …

Objective The objective of this review was to assess the burden of HIV drug resistance
mutations (DRM) in Indian adults exposed to first-line antiretroviral therapy (ART) as per …

Virus sequence data are an essential resource for reconstructing spatiotemporal dynamics
of viral spread as well as to inform treatment and prevention strategies. However, the …

Background Routine HIV-1 antiretroviral drug resistance testing for patients failing NNRTI-
based regimens is not recommended in resource-limited settings. Therefore, surveys are …

Despite expanded antiretroviral therapy (ART) in South Africa, HIV-1 transmission persists.
Integrase strand transfer inhibitors (INSTI) and long-acting injectables offer potential for …

Objective To determine the frequency and patterns of acquired antiretroviral drug resistance
in a rural primary health care programme in South Africa. Design Cross-sectional study …

Background Tenofovir (TDF) has replaced stavudine (d4T) as the preferred nucleoside
reverse transcriptase inhibitor (NRTI) in first-line regimens in South Africa, but limited …

The EuResist cohort was established in 2006 with the purpose of developing a clinical
decision-support tool predicting the most effective antiretroviral therapy (ART) for persons …

Introduction Tenofovir‐based first‐line antiretroviral therapy (ART) is recommended globally.
To evaluate the impact of its incorporation into the World Health Organization (WHO) …