Acute cerebral ischemia elicits an innate immune response that leads to a cascade of events
that culminates in necrotic death of neurons and injury to their supportive structures in the …

The excessive intake of alcohol is a serious public health problem, especially given the
severe damage provoked by chronic or prenatal exposure to alcohol that affects many …

Cannabinoids form a singular family of plant-derived compounds (phytocannabinoids),
endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple …

Although its presence in mammalian tissues has been known since the 1960s, N-palmitoyl-
ethanolamine (PEA) has emerged only recently among other bioactive N-acylethanolamines …

Neuroinflammation is a complex process involved in the physiophatology of many central
nervous system diseases, including addiction. Alcohol abuse is characterized by induction …

N-palmitoylethanolamine (PEA), an endogenous fatty acid ethanolamide, plays a key role in
the regulation of the inflammatory response and pain through, among others, activation of …

Autophagy may contribute to ischemia-induced cell death in the brain, but the regulation of
autophagic cell death is largely unknown. Nuclear factor kappa B (NF-κB) is a regulator of …

Cannabinoids (CBs) show promise as neuroprotectants with some agents already licensed
in humans for other conditions. We systematically reviewed CBs in preclinical stroke to …

Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …

The molecular pathways contributing to visual signal transduction in the retina generate a
high energy demand that has functional and structural consequences such as …