Nanopore-based technologies beyond DNA sequencing

YL Ying, ZL Hu, S Zhang, Y Qing, A Fragasso… - Nature …, 2022 - nature.com
Inspired by the biological processes of molecular recognition and transportation across
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …

Nonspecific binding—fundamental concepts and consequences for biosensing applications

A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Beyond mass spectrometry, the next step in proteomics

W Timp, G Timp - Science Advances, 2020 - science.org
Proteins can be the root cause of a disease, and they can be used to cure it. The need to
identify these critical actors was recognized early (1951) by Sanger; the first biopolymer …

Protein identification by nanopore peptide profiling

FLR Lucas, RCA Versloot, L Yakovlieva… - Nature …, 2021 - nature.com
Nanopores are single-molecule sensors used in nucleic acid analysis, whereas their
applicability towards full protein identification has yet to be demonstrated. Here, we show …

Bioinspired super‐wettability from fundamental research to practical applications

L Wen, Y Tian, L Jiang - Angewandte Chemie International …, 2015 - Wiley Online Library
Engineered wettability is a traditional, yet key issue in surface science and attracts
tremendous interest in solving large‐scale practical problems. Recently, different super …

Highly shape-and size-tunable membrane nanopores made with DNA

Y Xing, A Dorey, L Jayasinghe, S Howorka - Nature Nanotechnology, 2022 - nature.com
Membrane nanopores are key for molecular transport in biology, portable DNA sequencing,,–
, label-free single-molecule analysis,,,,,,,,–and nanomedicine. Transport traditionally relies …

Nanopore-based fourth-generation DNA sequencing technology

Y Feng, Y Zhang, C Ying, D Wang… - Genomics, Proteomics …, 2015 - academic.oup.com
Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have
the potential to quickly and reliably sequence the entire human genome for less than 1000 …

Building membrane nanopores

S Howorka - Nature nanotechnology, 2017 - nature.com
Membrane nanopores—hollow nanoscale barrels that puncture biological or synthetic
membranes—have become powerful tools in chemical-and biosensing, and have achieved …

Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore

F Piguet, H Ouldali, M Pastoriza-Gallego… - Nature …, 2018 - nature.com
There are still unmet needs in finding new technologies for biomedical diagnostic and
industrial applications. A technology allowing the analysis of size and sequence of short …

The application of single molecule nanopore sensing for quantitative analysis

Y Wu, JJ Gooding - Chemical Society Reviews, 2022 - pubs.rsc.org
Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …