Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Opioid use disorder is characterised by the persistent use of opioids despite the adverse
consequences of its use. The disorder is associated with a range of mental and general …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Importance Although clinical trials demonstrate the superior effectiveness of medication for
opioid use disorder (MOUD) compared with nonpharmacologic treatment, national data on …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

The widespread abuse of prescription opioids and a dramatic increase in the availability of
illicit opioids have created what is commonly referred to as the opioid epidemic. The …

Background A national crisis of opioid-related morbidity, mortality, and misuse has led to
initiatives to address the appropriate role of opioids to treat pain. Deployment of a guideline …

At least 2.3 million people in the US have an opioid use disorder, less than 40% of whom
receive evidence-based treatment. Buprenorphine used as part of medication-assisted …

Background Emergency department (ED)-initiated buprenorphine/naloxone with
continuation in primary care was found to increase engagement in addiction treatment and …