Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Consensus Statement on the definition and classification of metabolic hyperferritinaemia

L Valenti, E Corradini, LA Adams, E Aigner… - Nature Reviews …, 2023 - nature.com
Hyperferritinaemia is a common laboratory finding that is often associated with metabolic
dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron …

Pathophysiological, molecular and therapeutic issues of nonalcoholic fatty liver disease: an overview

S Marchisello, A Di Pino, R Scicali, F Urbano… - International journal of …, 2019 - mdpi.com
Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

[HTML][HTML] Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH

L Tao, X Yang, C Ge, P Zhang, W He, X Xu, X Li… - Cell Metabolism, 2024 - cell.com
The complex etiological factors associated with metabolic dysfunction-associated fatty liver
disease (MAFLD), including perturbed iron homeostasis, and the unclear nature by which …

Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets

LX Li, FF Guo, H Liu, T Zeng - Cellular and Molecular Life Sciences, 2022 - Springer
Alcoholic liver disease (ALD) is a global public health challenge due to the high incidence
and lack of effective therapeutics. Evidence from animal studies and ALD patients has …

Aging promotes metabolic dysfunction-associated steatotic liver disease by inducing ferroptotic stress

K Du, L Wang, JH Jun, RK Dutta, R Maeso-Díaz, SH Oh… - Nature Aging, 2024 - nature.com
Susceptibility to the biological consequences of aging varies among organs and individuals.
We analyzed hepatocyte transcriptomes of healthy young and aged male mice to generate …

Ultra‐processed food is associated with features of metabolic syndrome and non‐alcoholic fatty liver disease

D Ivancovsky‐Wajcman, N Fliss‐Isakov… - Liver …, 2021 - Wiley Online Library
Background & aims High consumption of ultra‐processed food (UPF) is associated with
mortality and chronic morbidity but has not been studied concerning to non‐alcoholic fatty …

Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with NAFLD

E Corradini, E Buzzetti, P Dongiovanni, S Scarlini… - Journal of …, 2021 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder
resulting from genetic and environmental factors. Hyperferritinemia has been associated …

Causal relationships between metabolic‐associated fatty liver disease and iron status: Two‐sample Mendelian randomization

H He, S Liao, Y Zeng, L Liang, J Chen… - Liver …, 2022 - Wiley Online Library
Abstract Background & Aims Dysregulated iron homeostasis plays an important role in the
hepatic manifestation of metabolic‐associated fatty liver disease (MAFLD). We investigated …

[HTML][HTML] Therapeutic potential of induced iron depletion using iron chelators in Covid-19

PP Naseef, M Elayadeth-Meethal, KTM Salim… - Saudi Journal of …, 2022 - Elsevier
Ferritin, which includes twenty-four light and heavy chains in varying proportions in different
tissues, is primarily responsible for maintaining the body's iron metabolism. Its normal value …