The peptides and proteins secreted by fungi are reviewed in this article. They include
ribosome inactivating peptides and proteins, antifungal peptides and proteins, lectins …

RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …

α‐Sarcin is a ribosome‐inactivating protein that has been well characterized in vitro, but little
is known about its toxicity in living cells. We have analyzed the mechanism of internalization …

A single-chain fusion protein that directed the cytolytic activity of α-sarcin to A33 tumor
antigen expressing cells was constructed and shown to effectively kill targeted cells …

Abstract α‐Sarcin is a ribotoxin secreted by the mold Aspergillus giganteus that degrades
the ribosomal RNA by acting as a cyclizing ribonuclease. Three residues potentially …

Ribotoxins are a family of highly specific fungal ribonucleases that inactivate the ribosomes
by hydrolysis of a single phosphodiester bond of the 28 S rRNA. α-Sarcin, the best …

The fungal pathogen Hirsutella thompsonii produces an insecticidal protein named
hirsutellin A (HtA), which has been described to be toxic to several species of mites, insect …

Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific
activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop …

α-Sarcin is a ribosome-inactivating protein from the moldAspergillus giganteus. The
methylotrophic yeastPichia pastorishas been transformed with two plasmids (pHILD2preαS …

Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases
(RNases) with antitumoral properties. However, the biological function of these toxic proteins …