Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of
virtually all tumors and strongly impact tumor progression. Despite increasing insight into …

Introduction Immune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer
therapy as single agents or in combination regimens both in adults and children …

Abstract Background Squamous cell carcinoma (SqCC) is a subtype of non-small cell lung
cancer for which patient prognosis remains poor. The extracellular matrix (ECM) is critical in …

Gastrointestinal tumors are responsible for more cancer-related fatalities than any other type
of tumors, and colorectal and gastric malignancies account for a large part of these …

Background: Ischemic heart disease following the obstruction of coronary vessels leads to
the death of cardiac tissue and the formation of a fibrotic scar. In contrast to adult mammals …

Angiogenesis, the formation of the new blood vessels from pre-existing vasculature, is an
essential process occurring under both normal and pathological conditions, such as …

Excessive fructose consumption is a primary contributor to the global surges in obesity,
cancer, and metabolic syndrome. Fructolysis is not robustly regulated and is initiated by …

The use of immune checkpoint inhibitors has revolutionized the treatment of melanoma
patients, leading to remarkable improvements in the cure. However, to ensure a safe and …

Oncogenic HPV E6 proteins have a PDZ-binding motif (PBM) which plays important roles in
both the viral life cycle and tumor development. The PBM confers interaction with a large …

Tumor angiogenesis is vital for the growth and development of various solid cancers and as
such is a valid and promising therapeutic target. Unfortunately, the use of the currently …