Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Networks are vital tools for understanding and modeling interactions in complex systems in
science and engineering, and direct and indirect interactions are pervasive in all types of …

A celebrated and controversial hypothesis suggests that some biological systems—parts,
aspects, or groups of them—may extract important functional benefits from operating at the …

RegulonDB, first published 20 years ago, is a comprehensive electronic resource about
regulation of transcription initiation of Escherichia coli K-12 with decades of knowledge from …

Genomics has set the basis for a variety of methodologies that produce high-throughput
datasets identifying the different players that define gene regulation, particularly regulation …

A promoter is a sequence of DNA that initializes the process of transcription and regulates
whenever and wherever genes are expressed in the organism. Because of its importance in …

Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

Motivation Being responsible for initiating transaction of a particular gene in genome,
promoter is a short region of DNA. Promoters have various types with different functions …

Carbohydrate-active enzyme (CAZymes) are not only the most important enzymes for
bioenergy and agricultural industries, but also very important for human health, in that …