Mitochondrial disorders are a heterogeneous group of often multisystemic and early fatal
diseases, which are amongst the most common inherited human diseases. These disorders …

The discovery of piezophiles (previously referred to as barophiles) prompted researchers to
investigate the survival strategies they employ in high-pressure environments. There have …

Glycation is an inevitable nonenzymatic covalent reaction between proteins and
endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein …

DNA damage induced by reactive carbonyls (mainly methylglyoxal and glyoxal), called DNA
glycation, is quantitatively as important as oxidative damage. DNA glycation is associated …

Mutations in DJ-1 cause recessively transmitted early-onset Parkinson disease (PD), and
oxidative damage to DJ-1 has been associated with the pathogenesis of late-onset sporadic …

Hsp31 encoded by hchA is known as a heat‐inducible molecular chaperone. Although
structure studies revealed that Hsp31 has a putative catalytic triad consisting of Asp‐214 …

The high resolution 2‐D protein gel electrophoresis technique combined with MALDI‐TOF
MS and a recently developed fluorescence‐based thiol modification assay were used to …

Elongation factor P (EF-P) is required for the efficient synthesis of proteins with stretches of
consecutive prolines and other motifs that would otherwise lead to ribosome pausing …

The MEROPS website (http://merops. sanger. ac. uk) includes information on peptidase
inhibitors as well as on peptidases and their substrates. Displays have been put in place to …

Energy-converting NADH: ubiquinone oxidoreductase, respiratory complex I, couples the
electron transfer from NADH to ubiquinone with the translocation of four protons across the …