Denosumab and bisphosphonates: different mechanisms of action and effects

R Baron, S Ferrari, RGG Russell - Bone, 2011 - Elsevier
To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid
arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb …

[HTML][HTML] A review of the latest insights into the mechanism of action of strontium in bone

D Marx, AR Yazdi, M Papini, M Towler - Bone reports, 2020 - Elsevier
Interest in strontium (Sr) has persisted over the last three decades due to its unique
mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast …

Postmenopausal osteoporosis

R Eastell, TW O'Neill, LC Hofbauer… - Nature reviews Disease …, 2016 - nature.com
Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …

The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro

E Gentleman, YC Fredholm, G Jell, N Lotfibakhshaiesh… - Biomaterials, 2010 - Elsevier
Bioactive glasses (BG) which contain strontium have the potential to combine the known
bone regenerative properties of BG with the anabolic and anti-catabolic effects of strontium …

The assessment of fracture risk

A Unnanuntana, BP Gladnick, E Donnelly, JM Lane - JBJS, 2010 - journals.lww.com
The Assessment of Fracture Risk : JBJS The Assessment of Fracture Risk : JBJS JBJS Journal
Case Connector Reviews JBJS.org Surgical Techniques Open Access JOPA Log in Subscribe …

Федеральные клинические рекомендации по диагностике, лечению и профилактике остеопороза

ГА Мельниченко, ЖЕ Белая… - Проблемы …, 2017 - cyberleninka.ru
Скрининг для выявления групп с высокой вероятностью переломов рекомендован с
использованием алгоритма FRAX среди всех женщин в постменопаузе и мужчин …

Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis

Z Saidak, PJ Marie - Pharmacology & therapeutics, 2012 - Elsevier
Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis

BZ Leder, LSL O'Dea, JR Zanchetta… - The Journal of …, 2015 - academic.oup.com
Context: Abaloparatide is a novel synthetic peptide analog of parathyroid hormone-related
protein (PTHrP) that is currently being developed as a potential anabolic agent in the …

Osteoporosis therapies and their mechanisms of action

B Kim, YJ Cho, W Lim - Experimental and therapeutic …, 2021 - spandidos-publications.com
Osteoporosis is a common disease that affects millions of patients worldwide and is most
common in menopausal women. The main characteristics of osteoporosis are low bone …

Teriparatide for osteoporosis: importance of the full course

R Lindsay, JH Krege, F Marin, L Jin… - Osteoporosis international, 2016 - Springer
Teriparatide (TPTD) is the only currently available therapeutic agent that increases the
formation of new bone tissue and can provide some remediation of the architectural defects …