Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Efficient and safe methods for delivering genetic materials into cells must be developed
before the clinical potential of gene therapy can be fully realized. Recently, hydrodynamic …

RNA interference is an evolutionarily conserved surveillance mechanism that responds to
double-stranded RNA by sequence-specific silencing of homologous genes. Here we show …

Hepatitis B virus (HBV) is a prototype for liver-specific pathogens in which the failure of the
immune system to mount an effective response leads to chronic infection. Our understanding …

An animal model for human hepatitis B virus (HBV) tolerance is needed to investigate the
mechanisms. This model will also facilitate therapeutic strategies for the existing 350 million …

We have reported that a rapid tail vein injection of a large volume of plasmid DNA solution
into a mouse results in high level of transgene expression in the liver. Gene transfer …

Hepatitis delta virus (HDV) is a sub-viral agent that is dependent for its life cycle on hepatitis
B virus (HBV). The help it obtains from HBV is limited to the sharing of envelope proteins …

The key to the discovery of the Hepatitis D Virus (HDV) was the description in Turin, Italy in
the mid-1970s of the delta antigen and antibody in carriers of the hepatitis B surface antigen …

Twenty-five years ago Rizzetto et al.[1], while examining liver biopsies from individuals
infected with HBV, discovered by immunofluorescence a previously unrecognized nuclear …

Hepatitis D is the most severe viral hepatitis. Hepatitis D virus (HDV) has a very small RNA
genome with unique biological properties. It requires for infection the presence of hepatitis B …