Complex multifactorial diseases such as allergic rhinitis and asthma are not only becoming
an increasing burden to healthcare systems, but especially affect the life quality of children …

Background: The secretion of alarmin cytokines by epithelial cells, including thymic stromal
lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, initiates inflammatory cascades in …

Mild to moderate equine asthma syndrome (mEAS) affects horses of all ages and breeds. To
date, the etiology and pathophysiology of mEAS are active areas of research, and it remains …

Histamine is an important mediator in the pathogenesis of asthma. Variation in genes along
the histamine production, response, and degradation pathway may be important in …

Host susceptibility to environmental triggers is the most likely explanation for the
development of asthma. Quantifying gene expression levels in disease-relevant tissues and …

Objective: Histamine is an important mediator in the pathophysiology of asthma. We have
previously reported that HRH1 is differentially expressed among those with asthma …

Asthma is characterized by recurrent episodes of wheezing, shortness of breath, chest
tightness, and coughing. It is usually caused by a combination of complex and incompletely …

Oral squamous cell carcinoma (OSCC) is the most frequently encountered type of oral
cancer. Histamine receptor H1 (HRH1) was reported to play a crucial role in OSCC …

Medical research in children typically lags behind that of adult research in both quantity and
quality. The conduct of rigorous clinical trials in children can raise ethical concerns because …

The expression profile of various genes in epithelial cells of the bronchi will enable the
diagnosis of molecular subphenotypes of asthma: a) asthma with strong features of Th2 …