A 5′ UTR language model for decoding untranslated regions of mRNA and function predictions
Abstract The 5′ untranslated region (UTR), a regulatory region at the beginning of a
messenger RNA (mRNA) molecule, plays a crucial role in regulating the translation process …
messenger RNA (mRNA) molecule, plays a crucial role in regulating the translation process …
Decoding biology with massively parallel reporter assays and machine learning
Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of
sequence variation on gene expression. Reading out molecular phenotypes with …
sequence variation on gene expression. Reading out molecular phenotypes with …
Current limitations in predicting mRNA translation with deep learning models
N Schlusser, A González, M Pandey, M Zavolan - Genome Biology, 2024 - Springer
Background The design of nucleotide sequences with defined properties is a long-standing
problem in bioengineering. An important application is protein expression, be it in the …
problem in bioengineering. An important application is protein expression, be it in the …
[HTML][HTML] mRNA Vaccine Sequence and Structure Design and Optimization: Advances and Challenges
L Jin, Y Zhou, S Zhang, SJ Chen - Journal of Biological Chemistry, 2024 - Elsevier
Messenger RNA (mRNA) vaccines have emerged as a powerful tool against communicable
diseases and cancers, as demonstrated by their huge success during the coronavirus …
diseases and cancers, as demonstrated by their huge success during the coronavirus …
Unveil cis-acting combinatorial mRNA motifs by interpreting deep neural network
Cis-acting mRNA elements play a key role in the regulation of mRNA stability and translation
efficiency. Revealing the interactions of these elements and their impact plays a crucial role …
efficiency. Revealing the interactions of these elements and their impact plays a crucial role …
Utrgan: Learning to generate 5'utr sequences for optimized translation efficiency and gene expression
Abstract The 5'untranslated region (5'UTR) of the messenger RNA plays a crucial role in the
translatability and stability of the molecule. Thus, it is an important component in the design …
translatability and stability of the molecule. Thus, it is an important component in the design …