ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

Biomarkers associated with COVID-19 disease progression

G Ponti, M Maccaferri, C Ruini, A Tomasi… - Critical reviews in …, 2020 - Taylor & Francis
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a scientific, medical, and
social challenge. The complexity of the severe acute respiratory syndrome coronavirus 2 …

Nicotine and the renin-angiotensin system

JM Oakes, RM Fuchs, JD Gardner… - American Journal …, 2018 - journals.physiology.org
Cigarette smoking is the single most important risk factor for the development of
cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has been in …

The anti-inflammatory effect of taurine on cardiovascular disease

T Qaradakhi, LK Gadanec, KR McSweeney… - Nutrients, 2020 - mdpi.com
Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With
its unique sulfonic acid makeup, taurine influences cellular functions, including …

Potential detrimental role of soluble ACE2 in severe COVID‐19 comorbid patients

MM Rahman, M Hasan, A Ahmed - Reviews in Medical Virology, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) enters the host cell by
binding to angiotensin‐converting enzyme 2 (ACE2) receptor. Other important proteins …

Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data

AM South, HA Shaltout, LK Washburn… - Clinical …, 2019 - portlandpress.com
Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious
worldwide health concern and a significant healthcare burden. As the majority of …

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

K Yamamoto, H Takeshita, H Rakugi - Clinical Science, 2020 - portlandpress.com
Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

Renin–angiotensin system: an important player in the pathogenesis of acute respiratory distress syndrome

J Hrenak, F Simko - International journal of molecular sciences, 2020 - mdpi.com
Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation,
increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very …

The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: key agents for treatment

ER Lumbers, R Head, GR Smith… - Pharmacology …, 2022 - Wiley Online Library
SARS‐CoV‐2 interacting with its receptor, angiotensin‐converting enzyme 2 (ACE2), turns
the host response to viral infection into a dysregulated uncontrolled inflammatory response …

The vasoactive Mas receptor in essential hypertension

AL Povlsen, D Grimm, M Wehland, M Infanger… - Journal of Clinical …, 2020 - mdpi.com
The renin–angiotensin–aldosterone system (RAAS) has been studied extensively, and with
the inclusion of novel components, it has become evident that the system is much more …