Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo
transient or longer-term interactions with other extracellular matrix components. They share …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Background As core units of organ tissues, cells of various types play their harmonious
rhythms to maintain the homeostasis of the human body. It is essential to identify the …

Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that
monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs])(1) are a …

Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Id proteins are important parts of signaling pathways involved in development, cell cycle and
tumorigenesis. They were first shown to act as dominant negative antagonists of the basic …

Over the past few decades, biologists have identified key molecular signatures associated
with a wide range of human cancers. Recently, animal models have been particularly useful …

Biochemical studies in endothelial cells (ECs) and genetic studies in mice and humans have
yielded major insights into the role of transforming growth factor β (TGF-β) and its …

It is here demonstrated that the set of gene expressions underlying the angiogenic balance
in tissues can be molecularly reset en masse by a single protein. Using genome-wide …

In addition to long-term regulation of angiogenesis, angiogenic growth factor signalling
through nitric oxide (NO) acutely controls blood flow and haemostasis. Inhibition of this …