Accurate chromosome segregation depends on the proper attachment of sister kinetochores
to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is …

In most organisms, genome haploidization requires reciprocal DNA exchanges (crossovers)
between replicated parental homologs to form bivalent chromosomes. These are resolved to …

Bub1 is a multi-task protein kinase required for proper chromosome segregation in
eukaryotes. Impairment of Bub1 in humans may lead to chromosomal instability (CIN) or …

The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that
sister chromatids do not separate until all chromosomes are correctly bioriented during …

During mitosis, replicated chromosomes (sister chromatids) become attached at the
kinetochore by spindle microtubules emanating from opposite poles and segregate …

Chromosome structure is dynamically regulated during cell division, and this regulation is
dependent, in part, on condensin. The localization of condensin at chromosome arms is …

The spindle checkpoint is the prime cell-cycle control mechanism that ensures sister
chromatids are bioriented before anaphase takes place. Aurora B kinase, the catalytic …

The spindle checkpoint is a surveillance system acting in mitosis to delay anaphase onset
until all chromosomes are properly attached to the mitotic spindle [1, 2]. When the …

The eukaryotic genome consists of DNA molecules far longer than the cells that contain
them. They reach their greatest compaction during chromosome condensation in mitosis …

Cell division in mitosis and meiosis is governed by evolutionary highly conserved protein
kinases and phosphatases, controlling the timely execution of key events such as nuclear …