Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …

Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …

Opioid treatment of pain is generally safe with 0.5% or less events from respiratory
depression. However, fatalities are regularly reported. The only treatment currently available …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key roles in excitatory synaptic …

Excitatory neurotransmission mediated by NMDA (N-methyl-d-aspartate) receptors is
fundamental to the physiology of the mammalian central nervous system. These receptors …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …