Olfactory and other sensory impairments in Alzheimer disease

C Murphy - Nature Reviews Neurology, 2019 - nature.com
The vast increase in Alzheimer disease (AD) worldwide has grave implications for
individuals, family support systems and the health-care systems that will attempt to cope with …

Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers

JC Lee, SJ Kim, S Hong, YS Kim - Experimental & molecular medicine, 2019 - nature.com
Current technological advancements in clinical and research settings have permitted a more
intensive and comprehensive understanding of Alzheimer's disease (AD). This development …

[HTML][HTML] Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease

Y Koronyo, D Biggs, E Barron, DS Boyer, JA Pearlman… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. Noninvasive detection of Alzheimer's disease (AD) with high specificity and
sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective …

Spectral-domain OCT measurements in Alzheimer's disease: a systematic review and meta-analysis

VTT Chan, Z Sun, S Tang, LJ Chen, A Wong, CC Tham… - Ophthalmology, 2019 - Elsevier
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. The
relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease …

The retina as a window to the brain—from eye research to CNS disorders

A London, I Benhar, M Schwartz - Nature Reviews Neurology, 2013 - nature.com
Philosophers defined the eye as a window to the soul long before scientists addressed this
cliché to determine its scientific basis and clinical relevance. Anatomically and …

At the interface of sensory and motor dysfunctions and Alzheimer's disease

MW Albers, GC Gilmore, J Kaye, C Murphy… - Alzheimer's & …, 2015 - Elsevier
Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Ocular indicators of Alzheimer's: exploring disease in the retina

NJ Hart, Y Koronyo, KL Black… - Acta neuropathologica, 2016 - Springer
Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

M Koronyo-Hamaoui, Y Koronyo, AV Ljubimov… - Neuroimage, 2011 - Elsevier
Noninvasive monitoring of β-amyloid (Aβ) plaques, the neuropathological hallmarks of
Alzheimer's disease (AD), is critical for AD diagnosis and prognosis. Current visualization of …

Biomarkers for Alzheimer's disease early diagnosis

E Ausó, V Gómez-Vicente, G Esquiva - Journal of Personalized Medicine, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, affecting the central
nervous system (CNS) through the accumulation of intraneuronal neurofibrillary tau tangles …