Association between pathological and MRI findings in multiple sclerosis

M Filippi, W Brück, D Chard, F Fazekas… - The Lancet …, 2019 - thelancet.com
Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects

A Minagar, MH Barnett, RHB Benedict, D Pelletier… - Neurology, 2013 - AAN Enterprises
The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

DTI measurements in multiple sclerosis: evaluation of brain damage and clinical implications

E Sbardella, F Tona, N Petsas… - Multiple sclerosis …, 2013 - Wiley Online Library
Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of
demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded …

Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease

NS Ryan, S Keihaninejad, TJ Shakespeare… - Brain, 2013 - academic.oup.com
Amyloid imaging studies of presymptomatic familial Alzheimer's disease have revealed the
striatum and thalamus to be the earliest sites of amyloid deposition. This study aimed to …

Cognitive impairment in MS: impact of white matter integrity, gray matter volume, and lesions

HE Hulst, MD Steenwijk, A Versteeg, PJW Pouwels… - Neurology, 2013 - AAN Enterprises
Objective: To investigate whether extent and severity of white matter (WM) damage, as
measured with diffusion tensor imaging (DTI), can distinguish cognitively preserved (CP) …

Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination

C Guglielmetti, J Veraart, E Roelant, Z Mai, J Daans… - Neuroimage, 2016 - Elsevier
Although MRI is the gold standard for the diagnosis and monitoring of multiple sclerosis
(MS), current conventional MRI techniques often fail to detect cortical alterations and provide …

Thalamic injury and cognition in multiple sclerosis

M Amin, D Ontaneda - Frontiers in Neurology, 2021 - frontiersin.org
Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white
matter. Both cortical and deep gray matter injury is observed during the course of MS …

[HTML][HTML] Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: a multimodal imaging investigation

AM Racine, N Adluru, AL Alexander, BT Christian… - NeuroImage: Clinical, 2014 - Elsevier
Some cognitively healthy individuals develop brain amyloid accumulation, suggestive of
incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative …

Multiple sclerosis: altered thalamic resting-state functional connectivity and its effect on cognitive function

F Tona, N Petsas, E Sbardella, L Prosperini… - Radiology, 2014 - pubs.rsna.org
Purpose To investigate, by using resting-state (RS) functional magnetic resonance (MR)
imaging, thalamocortical functional connectivity (FC) and its correlations with cognitive …

Functional expansion of sensorimotor representation and structural reorganization of callosal connections in lower limb amputees

EL Simoes, I Bramati, E Rodrigues… - Journal of …, 2012 - Soc Neuroscience
Previous studies have indicated that amputation or deafferentation of a limb induces
functional changes in sensory (S1) and motor (M1) cortices, related to phantom limb pain …