Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

The dominant paradigm of “one gene, one target, one disease” has influenced many
aspects of drug discovery strategy. However, in recent years, it has been appreciated that …

Heat stress is a common and, therefore, an important environmental impact on cells and
organisms. While much attention has been paid to severe heat stress, moderate temperature …

Background Signaling networks in eukaryotes are made up of upstream and downstream
subnetworks. The upstream subnetwork contains the intertwined network of signaling …

Allosteric drugs are increasingly used because they produce fewer side effects. Allosteric
signal propagation does not stop at the 'end'of a protein, but may be dynamically transmitted …

The structure and dynamics of complex network systems are of current research interest. We
illustrate the dependency between the network topology and its function, considering the …

At the initial stage of drug discovery, identifying novel targets with maximal efficacy and
minimal side effects can improve the success rate and portfolio value of drug discovery …

Autophagy, a highly regulated self-degradation process of eukaryotic cells, is a context-
dependent tumor-suppressing mechanism that can also promote tumor cell survival upon …

Control theory is a well-established approach in network science, with applications in bio-
medicine and cancer research. We build on recent results for structural controllability of …

Targeted drugs are effective when they directly inhibit strong disease drivers, but only a
small fraction of diseases feature defined actionable drivers. Alternatively, network-based …