Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …

Single-cell metabolomics with mass spectrometry enables a large variety of metabolites to
be simultaneously detected from individual cells, without any preselection or labelling, to …

Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As
a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a …

Emerging evidence has demonstrated the vital role of metabolism in various diseases or
disorders. Metabolomics provides a comprehensive understanding of metabolism in …

Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical
chemistry, enabling the rapid, direct analysis of samples in their native state. Since the …

Simple Summary Cell-to-cell variation exists within a population of the same cell type due to
stochastic gene and protein expression and environmental factors. Studying such cellular …

Metabolomics at the single-cell level is of great importance to reveal phenotypic
heterogeneity and contribute to disease precision diagnosis. Owing to small sample volume …

Rationale The level of visual detail of a mass spectrometry image is dependent on the
spatial resolution with which it is acquired, which is largely determined by the focal diameter …

Here, we present a new application of desorption electrospray ionization (DESI) and laser
ablation electrospray ionization (LAESI) mass spectrometry imaging to assess the spatial …

The use of mass spectrometry (MS) to acquire molecular images of biological tissues and
other substrates has developed into an indispensable analytical tool over the past 25 years …