Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
Dendritic spine pathology in schizophrenia
JR Glausier, DA Lewis - Neuroscience, 2013 - Elsevier
Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …
impairments in perception, cognition and motivation. These impairments reflect alterations in …
Neuronal defects in a human cellular model of 22q11. 2 deletion syndrome
Abstract 22q11. 2 deletion syndrome (22q11DS) is a highly penetrant and common genetic
cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from …
cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from …
Transcriptional linkage analysis with in vivo AAV-Perturb-seq
The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …
demands new methods to study genotype–phenotype relationships in complex tissues in a …
Hippocampal-prefrontal interactions in cognition, behavior and psychiatric disease
T Sigurdsson, S Duvarci - Frontiers in systems neuroscience, 2016 - frontiersin.org
The hippocampus and prefrontal cortex (PFC) have long been known to play a central role
in various behavioral and cognitive functions. More recently, electrophysiological and …
in various behavioral and cognitive functions. More recently, electrophysiological and …
Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
MicroRNAs: key regulators in the central nervous system and their implication in neurological diseases
MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …
An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy
MJ Millan - Neuropharmacology, 2013 - Elsevier
Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …
development of the brain, leading to deficits in language, cognition, motor behaviour and …
The 22q11. 2 deletion syndrome as a window into complex neuropsychiatric disorders over the lifespan
RK Jonas, CA Montojo, CE Bearden - Biological psychiatry, 2014 - Elsevier
Evidence is rapidly accumulating that rare, recurrent copy number variants represent large
effect risk factors for neuropsychiatric disorders. 22q11. 2 deletion syndrome (22q11DS) …
effect risk factors for neuropsychiatric disorders. 22q11. 2 deletion syndrome (22q11DS) …
[HTML][HTML] The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications
Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …
develop autism and schizophrenia, disorders associated with altered GABAergic function …