Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

Granules are essential for the ability of neutrophils to fulfill their role in innate immunity.
Granule membranes contain proteins that react to environmental cues directing neutrophils …

Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Neutrophils are part of a family of granulocytes that, together with eosinophils and basophils,
play an essential role in innate immunity. Neutrophils are the most abundant circulating …

Gene expression profiling has revealed that circulating neutrophils rest between two major
bursts of transcriptional and protein synthetic activities. The first occurs in the bone marrow …

Neutrophil serine proteases are granule-associated enzymes known mainly for their function
in the intracellular killing of pathogens. Their extracellular release upon neutrophil activation …

Among the different proteoglycans expressed by mammals, serglycin is in most immune
cells the dominating species. A unique property of serglycin is its ability to adopt highly …