The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Plant fungal pathogens can have devastating effects on a wide range of crops, including
cereals and fruit (such as wheat and grapes), causing losses in crop yield, which are costly …

With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …

Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in
catalysis, cell signaling, and morphogenesis. Complete monospanning protein structures …

Azoles have been applied widely to combat pathogenic fungi in medicine and agriculture
and, consequently, loss of efficacy has occurred in populations of some species. Often, but …

Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …

Aspergillus fumigatus is the opportunistic fungal pathogen that predominantly affects the
immunocompromised population and causes 600,000 deaths/year. The cytochrome P450 …

While the orally-active azoles such as voriconazole and itraconazole are effective antifungal
agents, they potently inhibit a broad range of off-target human cytochrome P450 enzymes …

Fungal diseases are an increasing global burden. Fungi are now recognised to kill more
people annually than malaria, whilst in agriculture, fungi threaten crop yields and food …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …