Gene fusions have a pivotal role in non-small cell lung cancer (NSCLC) precision medicine.
Several techniques can be used, from fluorescence in situ hybridization and …

Highlights•New selective RET inhibitors have activity and favourable toxicity profiles in RET-
altered solid tumours.•There is a need to identify the optimal techniques to detect RET …

Simple Summary Lung cancer is still one of the most commonly diagnosed and deadliest
cancers in the world. Its diagnosis at an early stage is highly necessary and will improve the …

The Glial cell line-derived neurotrophic Family Ligands (GFL) are soluble neurotrophic
factors that are required for development of multiple human tissues, but which are also …

Based on superior efficacy and tolerability, targeted therapy is currently preferred over
chemotherapy and/or immunotherapy for actionable gene fusions that occur in late‐stage …

Neuregulins (NRGs) are a family of six related physiological ligands all containing a
receptor-binding epidermal growth factor (EGF)-like domain that mediate their binding to …

Simple Summary Non-small cell lung cancer (NSCLC) is the most common cancer in the
world. For common EGFR mutations, treatment is based on different inhibitors. Despite the …

Major advances in the treatment of non-small cell lung cancer (NSCLC) patients have been
obtained during the last decade. Molecular testing of tumor samples is therefore mandatory …

The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched
with new chemotherapy combinations and biological agents that lead to a remarkable …

Background Sensitive and reliable molecular diagnostics is needed to guide therapeutic
decisions for cancer patients. Although less material becomes available for testing, genetic …