The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

The sine oculis (SIX) family of transcription factors are key regulators of developmental
processes during embryogenesis. Members of this family control gene expression to …

SIX1 interacts with EYA to form a bipartite transcription factor essential for mammalian
development. Loss of function of this complex causes branchio-oto-renal (BOR) syndrome …

Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder
characterized by the association of branchial arch defects, hearing loss, and renal …

Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics,
transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic …

The hypothalamus, pituitary, and gonads coordinate to direct the development and
regulation of reproductive function in mammals. Control of the hypothalamic–pituitary …

The vertebrate Six1 and Six2 arose by gene duplication from the Drosophila sine oculis and
have since diverged in their developmental expression patterns. Both genes are expressed …

Myotonic dystrophy (DM), the most common form of adult onset muscular dystrophy, affects
skeletal muscle, heart, and the central nervous system (CNS). Mortality results primarily from …

In Drosophila, the sine oculis (so) gene is important for the development of the entire visual
system, including Bolwig's organ, compound eyes and ocelli. Together with twin of eyeless …

The initiation of eye formation in all seeing animals is controlled by a group of selector
genes that together forms the retinal determination cascade. In Drosophila, mice and …