Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …

The TGF-β1 cytokine is a key mediator of many biological processes. Complex regulatory
mechanisms are in place that allow one single molecule to exert so many distinct …

KRAS signaling is associated with cancer progression in several cancers. Upregulation of
KRAS signaling is often seen in cancers that harbor high KRAS mutation rate, such as …

The failure of immunotherapies in immune-excluded tumor (IET) is largely ascribed to the
void of intratumoral cytotoxic T cells (CTLs). The major obstacles are the excessive stroma …

Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year
survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of …

Background: KRAS G12D mutation subtype is present in over 40% of pancreatic ductal
adenocarcinoma (PDAC), one of the leading global causes of cancer death. This …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to its
aggressiveness and the challenges for early diagnosis and treatment. Recently …

Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of<
1%. With little improvement in survival rates observed in the past 40 years, there is a …