Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but
the software tools to analyse tandem mass spectra are lagging behind. We present a …

The proteasome is essential for the selective degradation of most cellular proteins, but how
cells maintain adequate amounts of proteasome is unclear. Here we show that there is an …

In recent years seaweeds have increasingly attracted interest in the search for new drugs
and have been shown to be a primary source of bioactive natural compounds and …

Synonymous codons encode the same amino acid, but differ in other biophysical properties.
The evolutionary selection of codons whose properties are optimal for a cell generates the …

In plants, iron uptake from the soil is tightly regulated to ensure optimal growth and
development. Iron absorption in Arabidopsis root epidermal cells requires the IRT1 …

Pathogens deliver complex arsenals of translocated effector proteins to host cells during
infection, but the extent to which these proteins are regulated once inside the eukaryotic cell …

Abstract G-quadruplexes (G4s) formed by guanine-rich nucleic acids induce genome
instability through impeding DNA replication fork progression. G4s are stable DNA …

Large-scale quantitative proteomics can provide a near-global view of cellular protein
abundance. Yet, the time, effort, and expertise required to achieve reasonable protein …

Fungal pathogens threaten ecosystems and human health. Understanding the molecular
basis of their virulence is key to develop new treatment strategies. Here, we characterize …

Mitochondrial cristae are extraordinarily crowded with proteins, which puts stress on the
bilayer organization of lipids. We tested the hypothesis that the high concentration of …