Phage display screening in breast cancer: From peptide discovery to clinical applications

AYW Ning, SCY Chun, YW Hsum, WC Loo, ACY Yin… - Life Sciences, 2024 - Elsevier
Breast cancer is known as the most common type of cancer found in women and a leading
cause of cancer death in women, with the global incidence only increasing. Breast cancer in …

Phage nanofibers in nanomedicine: Biopanning for early diagnosis, targeted therapy, and proteomics analysis

H Xu, B Cao, Y Li, C Mao - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
Display of a peptide or protein of interest on the filamentous phage (also known as
bacteriophage), a biological nanofiber, has opened a new route for disease diagnosis and …

Rational identification of a colorectal cancer targeting peptide through phage display

D Ferreira, AP Silva, FL Nobrega, IM Martins… - Scientific Reports, 2019 - nature.com
Colorectal cancer is frequently diagnosed at an advanced stage due to the absence of early
clinical indicators. Hence, the identification of new targeting molecules is crucial for an early …

Nanotechnology in targeted drug delivery and therapeutics

D Sousa, D Ferreira, JL Rodrigues… - Applications of targeted …, 2019 - Elsevier
Nanotechnology has countless applications in different fields. In health and biomedical
areas, it can be used in drug delivery and therapeutics. Nanocarriers are used in …

Phage Display Identified Peptide with Selectivity for Human Osteoarthritic Chondrocytes

IM Martins, RF Canadas, H Pereira… - Advanced …, 2023 - Wiley Online Library
Osteoarthritis (OA) is one of the most common joint disorders in western populations,
affecting millions of people worldwide and with a rising incidence as life expectancy …

Smart Targeted-Nanocarriers for Cancer Therapeutics

D Ferreira, R Silva, L Figueiredo… - Biogenic Nanomaterials for …, 2024 - Springer
The main hindrance in modern nanomedicine includes drug non-specific tissue
biodistribution. This is particularly important for cancer, which is the second leading cause of …

[HTML][HTML] Synergistic effect of pyrazoles derivatives and doxorubicin in claudin-low breast cancer subtype

S Saueressig, J Tessmann, R Mastelari… - Biomedicine & …, 2018 - Elsevier
Background Breast cancer is a global public health problem. For some subtypes, such as
Claudin-low, the prognosis is poorer and the treatment is still a challenge. Pyrazoles are an …

Propagation Capacity of Phage Display Peptide Libraries Is Affected by the Length and Conformation of Displayed Peptide

D Kamstrup Sell, AW Sinkjaer, B Bakhshinejad, A Kjaer - Molecules, 2023 - mdpi.com
The larger size and diversity of phage display peptide libraries enhance the probability of
finding clinically valuable ligands. A simple way of increasing the throughput of selection is …

Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer

L Hou, Y Hou, Y Liang, B Chen, X Zhang… - Communications …, 2022 - nature.com
To explore highly selective targeting molecules of colorectal cancer (CRC) is a challenge.
We previously identified a twelve-amino acid peptide (LPKTVSSDMSLN, namely P-LPK) by …

Selection of a new peptide homing SK‐BR‐3 breast cancer cells

AC Pereira, D Ferreira… - Chemical Biology & …, 2021 - Wiley Online Library
Breast cancer diagnosis remains a challenge, mostly due to its heterogeneity. This reality
translates in delayed treatments, increasing treatment aggressiveness and lower chances of …