Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

Supramolecular or molecular gels are attractive for various applications, including
diagnostics, tissue scaffolding and targeted drug release. Gelators derived from natural …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Molecular self‐assembly is central to many processes in both biology and supramolecular
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …

We have investigated the structures formed by oligonucleotides composed of two or four
repeats of the telomeric sequences from Oxytricha and Tetrahymena. The Oxytricha four …

We have used two-dimensional 1H NMR spectroscopy to study the conformation of the
thrombin-binding aptamer d (GGTTGGTGTGGTTGG) in solution. This is one of a series of …

Hydrogen bonds are like human beings in the sense that they exhibit typical grouplike
behavior. As an individual they are feeble, easy to break, and sometimes hard to detect …

Abstract RNA G-quadruplex (RG4) structures are involved in multiple biological processes.
Recent genome-wide analyses of human mRNA transcriptome identified thousands of …

Single-stranded complex guanine-rich DNA sequences from chromosomal telomeres and
else-where can associate to form stable parallel four-stranded structures termed G4-DNA by …

Nature's use of a simple genetic code to enable life's complex functions is an inspiration for
supramolecular chemistry. DNA nucleobases carry the key information utilizing a variety of …