DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the
expression and mobility of transposable elements (TEs). Owing to their ability to recruit the …

DNA and histone methylation are linked and subjected to mitotic inheritance in mammals.
Yet how methylation is propagated and maintained between successive cell divisions is not …

Dnmt3a and Dnmt3b are responsible for the establishment of DNA methylation patterns
during development. These proteins contain, in addition to a C-terminal catalytic domain, a …

DNA hypomethylation is a hallmark of many types of solid tumors. However, it remains
elusive how DNA hypomethylation may contribute to tumorigenesis. In this study, we have …

The deposition of DNA methylation at promoters of transposons, X-linked genes, imprinted
genes, and other lineage-specific genes is clearly associated with long-term transcriptional …

Abstract LSH, a SNF2 family DNA helicase, is a key regulator of DNA methylation in
mammals. How LSH facilitates DNA methylation is not well defined. While previous studies …

Deletion of Lsh perturbs DNA methylation patterns in mice yet it is unknown whether Lsh
plays a direct role in the methylation process. Two types of methylation pathways have been …

ICF (Immunodeficiency, Centromeric instability and Facial anomalies) syndrome is a rare
autosomal recessive disease caused by mutations in the DNA methyltransferase gene …

Diabetes is a metabolic disorder and its incidence is still increasing. Diabetic vascular
complications cause major diabetic mobility and include accelerated atherosclerosis …