[HTML][HTML] Understanding apoptosis in sickle cell anemia patients: Mechanisms and implications

EI Obeagu, NI Ubosi, GU Obeagu, SI Egba, MH Bluth - Medicine, 2024 - journals.lww.com
Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of
abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much …

[HTML][HTML] Stress erythropoiesis: definitions and models for its study

RF Paulson, S Hariharan, JA Little - Experimental hematology, 2020 - Elsevier
Highlights•Stress erythropoiesis is a complex response to anemic stress.•Increased steady-
state erythropoiesis is driven by Epo.•Inflammation impairs steady-state erythropoiesis and …

The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus

SM Robert, BC Reeves, E Kiziltug, PQ Duy, JK Karimy… - Cell, 2023 - cell.com
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …

Targeting the heme-heme oxygenase system to prevent severe complications following COVID-19 infections

FA Wagener, P Pickkers, SJ Peterson, S Immenschuh… - Antioxidants, 2020 - mdpi.com
SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19
patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and …

Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage

GP Page, T Kanias, YJ Guo, MC Lanteri… - The Journal of …, 2021 - Am Soc Clin Investig
Background The evolutionary pressure of endemic malaria and other erythrocytic pathogens
has shaped variation in genes encoding erythrocyte structural and functional proteins …

Sickle cell disease update: new treatments and challenging nutritional interventions

V Bell, T Varzakas, T Psaltopoulou, T Fernandes - Nutrients, 2024 - mdpi.com
Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a
congenital blood disorder characterized by considerable phenotypic diversity. It comprises a …

[HTML][HTML] Oxidative stress and Erectile Dysfunction: pathophysiology, impacts, and potential treatments

A Kaltsas, A Zikopoulos, F Dimitriadis, D Sheshi… - Current Issues in …, 2024 - mdpi.com
Erectile dysfunction (ED) is a prevalent condition affecting men's sexual health, with
oxidative stress (OS) having recently been identified as a significant contributing causative …

Hyperviscosity syndrome in COVID-19 and related vaccines: exploring of uncertainties

HM Al-Kuraishy, AI Al-Gareeb, MM El-Bouseary… - Clinical and …, 2023 - Springer
Hyperviscosity syndrome (HVS) recently emerged as a complication of coronavirus disease
2019 (COVID-19) and COVID-19 vaccines. Therefore, the objectives of this critical review …

iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays

ME Fay, O Oshinowo, E Iffrig, KS Fibben… - Nature …, 2023 - nature.com
While microscopy-based cellular assays, including microfluidics, have significantly
advanced over the last several decades, there has not been concurrent development of …

A review of the relationship between the immune response, inflammation, oxidative stress, and the pathogenesis of sickle cell anaemia

FI Aboderin, T Oduola, GM Davison, OO Oguntibeju - Biomedicines, 2023 - mdpi.com
Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …