Abstract Obesity contributes 65–75% of the risk for human primary (essential) hypertension
(HT) which is a major driver of cardiovascular and kidney diseases. Kidney dysfunction …

Immune mechanisms have been recognized to have a role in the pathogenesis of
hypertension, vascular disease and kidney damage in humans and animals for many …

Albuminuria is closely associated with stroke and cardiovascular diseases (CVDs) as well
as the salt sensitivity of blood pressure (BP). Although albuminuria may reflect generalized …

MicroRNAs are endogenous repressors of gene expression. We examined microRNAs in
the renal medulla of Dahl salt-sensitive rats and consomic SS-13BN rats. Salt-induced …

The importance of the immune system in hypertension, vascular disease, and renal disease
has been appreciated for over 50 years. Recent experimental advances have led to a …

Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …

Background Aberrant microRNA (miRNA) expression affects biologic processes and
downstream genes that are crucial to CKD initiation or progression. The miRNA miR-204-5p …

Summary NAD (P) H oxidase has been shown to be important in the development of salt-
sensitive hypertension. Here, we show that the expression of a subunit of NAD (P) H …

The physiological evidence linking the production of superoxide, hydrogen peroxide, and
nitric oxide in the renal medullary thick ascending limb of Henle (mTAL) to regulation of …

Increased central venous pressure in congestive heart failure causes renal dysfunction;
however, the underlying mechanisms are unclear. We created a rat renal congestion model …