New challenges of HIV-1 infection: how HIV-1 attacks and resides in the central nervous system

V Rojas-Celis, F Valiente-Echeverría, R Soto-Rifo… - Cells, 2019 - mdpi.com
Acquired immunodeficiency syndrome (AIDS) has become one of the most devastating
pandemics in recorded history. The main causal agent of AIDS is the human …

HIV‐Associated Neurotoxicity: The Interplay of Host and Viral Proteins

S Jadhav, V Nema - Mediators of Inflammation, 2021 - Wiley Online Library
HIV‐1 can incite activation of chemokine receptors, inflammatory mediators, and glutamate
receptor‐mediated excitotoxicity. The mechanisms associated with such immune activation …

HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing

S Yandrapally, S Sarkar, S Banerjee - Journal of Virology, 2023 - Am Soc Microbiol
Proliferation of HIV in astrocytes is limited when compared to CD4+ T lymphocytes, but the
molecular mechanisms behind the disparity in cell-specific HIV propagations are unclear. In …

Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND

J Marino, ME Maubert, AR Mele, C Spector… - Cellular and Molecular …, 2020 - Springer
Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) is a potent
mediator involved in the development of HIV-1-associated neurocognitive disorders …

Chronic inflammation mediates brain injury in HIV infection: relevance for cure strategies

JC McArthur, TP Johnson - Current opinion in neurology, 2020 - journals.lww.com
As therapies are developed to cure HIV, it is important to protect the CNS from additional
immune-mediated damage. Adjunctive therapies to restore glial function, reduce …

FOXO3a accumulation and activation accelerate oxidative stress‐induced podocyte injury

X Chen, W Liu, J Xiao, Y Zhang, Y Chen… - The FASEB …, 2020 - Wiley Online Library
Podocyte injury is the primary cause of glomerular injury in diabetic nephropathy (DN).
Advanced oxidation protein products (AOPPs), the triggers and markers of oxidative stress in …

Pharmacological inhibition of UPR sensor PERK attenuates HIV Tat‐induced inflammatory M1 phenotype in microglial cells

DB Silveira, MF Américo, NP Flores… - Cell Biochemistry …, 2022 - Wiley Online Library
HIV‐1‐associated neurocognitive disorders (HAND) are a major concern in HIV‐infected
individuals despite the currently available antiretroviral therapy regime. Impaired M1 pro …

Sirtuins modulation: a promising strategy for HIV-associated neurocognitive impairments

I Figarola-Centurión, M Escoto-Delgadillo… - International Journal of …, 2022 - mdpi.com
HIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it
persists in 40% of this population. Nowadays, HAND neuropathogenesis is considered to be …

Caffeine upregulates SIRT3 expression to ameliorate astrocytes-mediated HIV-1 Tat neurotoxicity via suppression of EGR1 signaling pathway

L Gao, W Sun, L Zhang, C Liang, D Zhang - Journal of NeuroVirology, 2024 - Springer
Caffeine is one of the most popular consumed psychostimulants that mitigates several
neurodegenerative diseases. Nevertheless, the roles and molecular mechanisms of caffeine …

Win55, 212-2 improves neural injury induced by HIV-1 glycoprotein 120 in rats by exciting CB2R

L Wang, Y Zeng, Y Zhou, J Yu, M Liang, L Qin… - Brain Research …, 2022 - Elsevier
The occurrence and development of HIV-associated neurocognitive disorders (HAND) is
related to synaptic injury and neuron loss, which gradually reduces the ability of learning …