Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Drug resistance is a primary cause of chemotherapeutic failure; however, how this
resistance develops is complex. A comprehensive understanding of chemotherapeutic …

Objective Preeclampsia (PE) affects many women globally and remains a primary cause of
neonatal and maternal morbidity and mortality. Aberrant placental microRNA (miRNA) …

Conventional osteosarcoma (OS) is a high-grade intraosseous malignancy with production
of osteoid matrix; however, a deeper dive into the underlying genetics reveals genomic …

Energy metabolism reprogramming is the characteristic feature of tumors. The
tumorigenesis, metastasis, and drug resistance of ovarian cancer (OC) is dependent on …

Background The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several
types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene …

Emerging evidence links the growth hormone (GH)-insulin-like growth factor-1 (IGF1)
endocrine axis to cancer development. While this putative correlation is of major …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐
arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss …

Introduction: The insulin-like growth factors (IGFs) are a family of secreted peptide hormones
with important roles in different cellular and organism functions. The biological activities of …