The adenosine A2A receptor subtype is recognized as a non-dopaminergic
pharmacological target for the treatment of neurodegenerative disorders, notably …

Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies
associate higher coffee consumption with decreased rates of mortality and decreased rates …

Background The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is
incomplete and may be influenced by environmental and/or other genetic factors …

Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and
environmental factors interact to contribute to its etiology. Remarkable progress has been …

Background Aging is the strongest risk factor for Parkinson's disease (PD), which is a
clinically heterogeneous movement disorder with highly variable age at onset. DNA …

Abstract Purpose of Review Genetic variants in GBA1 and LRRK2 genes are the commonest
genetic risk factor for Parkinson disease (PD); however, the preclinical profile of GBA1 and …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. Genetic modifiers,
environmental factors and gene–environment interactions have been found to modify PD …

The adenosine A 2A receptor is a major target of caffeine, the most widely used
psychoactive substance worldwide. Large epidemiological studies have long shown …

Several phenotypic differences observed in Parkinson's disease (PD) patients have been
linked to age at onset (AAO). We endeavoured to find out whether these differences are due …

Missense mutations in the LRRK2 gene were first identified as a pathogenic cause of
Parkinson's disease (PD) in 2004. Soon thereafter, a founder mutation in LRRK2, p. G2019S …